Impact of polymorphisms of the DNA repair gene XRCC1 and their role in the risk of prostate cancer

ABSTRACT

We conducted a case-control study to examine the role of XRCC1 codons 194 [Arg>Trp], 280 [Arg>His] and 399 [Arg>Gln] polymorphisms in the risk of prostate cancer. This study included 572 consecutive primary prostate cancer patients and 572 controls between January 2011 and January 2014. The polymerase chain reaction-restriction fragment length polymorphism [PCR-RFLP] was performed to detect XRCC1 codons 194 [Arg>Trp], 280 [Arg>His] and 399 [Arg>Gln] polymorphisms. Compared with the control subjects, the prostate cancer cases had a habit of cigarette smoking [x[2]=18.13, P<0.001] and a family history of cancer [x[2]=25.23, P<0.001]. Conditional logistic regression analysis showed that the subjects carrying Trp/Trp genotype were more likely to greatly increase the prostate cancer when compared with Arg/Arg genotype, and the adjusted OR was 2.04 [1.24-3.41]. We did not find significant association between XRCC1 194 [Arg>Trp] polymorphism and clinical stage and Gleason score of prostate cancer [P>0.05]. Our results show an increased risk for prostate cancer in individuals with XRCC1 194 [Arg>Trp] polymorphism, and a significant interaction between XRCC1 194 [Arg>Trp] polymorphism and tobacco smoking, alcohol drinking and family history of cancer