Hepatotoxicity to different antituberculosis drug combinations
JPMA-Journal of Pakistan Medical Association. 1990; 40 (12): 290-294
in English
| IMEMR
| ID: emr-16809
ABSTRACT
Hepatotoxicity to different combinations of anti-tuberculosis drugs containing, Rifampicin [R], Streptomycin [S], Isoniazid [H], Pyrazinamide [Z] and Myambutol [E] is described in 47 patients who completed 6 to 9 months therapy. Seven cases [15%] showed signs of toxicity and in 4 patients [8.5%] the drugs had to be withdrawn. Two patients developed hepatitis, one with jaundice and the other with fever and deranged liver functions, while others 2 developed severe hypersensitivity reactions. Burning palms, difficulty in micturition, itching and giddiness were complained of by one patient each, which settled in due course without recourse to withdrawal of drugs
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
J. Pak. Med. Assoc.
Year:
1990
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