association of elevated serum Alanine aminotransferase with metabolic syndrome in a military population in Southern Iran

ABSTRACT

Metabolic syndrome [MetS] is rapidly rising at an alarming rate through all parts of the world. Elevated serum aminotransferase was proposed as a marker for early detection of MetS. In this investigation we primarily aimed to evaluate the prevalence of MetS and its components among army and secondly to explore the association between elevated serum aminotransferase and the components of metabolic syndrome. A total of 380 army personnel from a military camp in Southern Iran participated in this cross-sectional study. Life style related characteristics, anthropometric features, serum aminotransferase and components of MetS, based on National Cholesterol Education Program-Adult Treatment Panel III, were measured. Statistical significant was set as p value less than 0.05. The mean age of participants was 35.0 +/- 7.5 year-old and the prevalence of metabolic syndrome was 8.1%. The prevalence of the components of MetS including; central obesity, abnormal fasting blood glucose, hypertension, hypertriglycridemia and low HDL cholesterol level was 8.6%, 10.4%, 18.5%, 31%, and 45.5% respectively. MetS had significant relationship with obesity [P<0.001] and abnormal Waist Circumferance/Hip Circumference ratio [P<0.001]. Twenty-six percent of subjects had ALT >/= 41 U/L and 4.9% of them had ALT >/= 81. Elevated serum aminotransferase had significant association with presence of MetS [P= 0.007]. Although prevalence of metabolic syndrome among the studied army population was not high, life style modification of army members is recommended. Liver function tests should be included in routine health checkup of military personnel