Comparison of hemodynamic changes in administration of ondansetron and metoclopramide to preventing post-operative nausea and vomiting after strabism surgery

ABSTRACT

The aim of the present study was to compare the hemodynamic changes of intravenous ondansetron and metoclopramide for prevention of post-operative nausea and vomiting in patients undergoing strabism surgery under general anesthesia. This is a randomized double blind clinical trial performed on 96 patients with average age of 6-12y/o, ASA [American Society of Anesthesiologists] physical status I and 11 candidates for strabism surgery with general anesthesia between the years 2009 till July 2010. After the hospital's Ethic Committee approval, the study was conducted in Tabriz University of Medical Sciences, Tabriz, Iran. The patients were randomized into two groups, ondansetron [n=48] and metoclopramide [n =48]. In this study ondansetron 50pg/kg and metoclopramide 150pg/kg administered intravenously five minutes before induction of general anesthesia after routine monitoring. Systolic and diastolic blood pressure and heart rate were measured as hemodynamic variables in both groups. In recovery room Aldrete scoring system employed as the patients' discharge criteria. Incidence and severity of post-operative nausea and vomiting documented in recovery room and in different times in surgical ward by using a specified scoring system and getting information from patients and their caregivers. There were not significant differences between two groups in demographics, hemodynarnic parameters and anesthesia length. There was not also significant difference about the incidence and severity of nausea and vomiting between two groups. It is concluded that preoperative administration of both ondansetron and metoclopramide can decrease frequency and also intensity of post-operative nausea and vomiting without having significant difference and prominent complication