Evaluation of plasma adiponectin level in patients with nonalcoholic fatty liver disease

ABSTRACT

Nonalcoholic fatty liver disease is an increasingly recognized condition that may progress to end stage liver disease; the aim was to study the level of plasma adiponectin in patients with nonalcoholic fatty liver with DM, and chronic hepatitis C in comparison with a control group. The study was conducted on 60 individuals, 37 males and 23 females, their age ranged from 26 to74 Ys, they were categorized into 3 groups G 1 20 apparently healthy individual serving as a control group, G2 20 patients with type 2 DM and fatty liver, G 3 20 patients with chronic hepatitis C and fatty liver. All cases underwent full clinical examination and laboratory investigaions, including [CBC], [ESR], liver and kidney- function tests ,fasting and 2hours PP blood glucose, lipograms, Polymerase chain reaction [PCR] for HCV-RNA in addition to abdominal ultrasonography and estimation of serum adiponectin level by ELISA technique. A significantly decreased plasma adiponectin levels were found in patients with fatty liver disease when compared to the control group. In addition, plasma adiponectin in group 2 [DM] show significant positive correlation with fasting blood glucose level [r =-52, p<0.05]. However plasma adiponectin levels, were significantly lower in group 3 [HCV] than in the other groups. A significant lower adiponectin levels was observed in male in all groups, further more plasma adiponectin in group 3 [HCV] show significant spositive correlation with blood urea [r =0.48, p <0.05] and HDL level [r =0.49, p <0.05]. Plasma adiponectin level is decreased in patients with NAFLD with type2 DM and chronic HCV and may suggest fat accumulation in the liver