Benha Medical Journal. 2007; 24 (2): 533-542
in English
| IMEMR
| ID: emr-168604
ABSTRACT
In this double blind randomized study we compared. The effects of epidural nalbuphine to intravenous [IV] nalbuphine on the epidural morphine in patients undergoing elective major abdominal surgery. G[M] [control group] received epidural mixture of bupivacaine 0.5% 1mg/kg and preservative free morphine 150 micro g/ml bupivacaine G[M-epiN] received epidural mixture of bupivacaine 0.5% 1mg/kg and preservative free morphine 150 micro g /ml bupivacaine and preservative and buffer free nalbuphine 30 micro g/mL bupivacaine G[MivN] received epidural mixture of bupivacaine 0.5% 1mg/kg and preservative free morphine 150 micro g/ml bupivacaine and preservative and buffer free nalbuphine 0.1mg/kg [IV] There was no significant changes in analgesia score or sedation score between 3 groups. Nalbuphine markedly adverse the side effects of morphine regarding haemodynamics. There was significant decrease in HR and MAP in the G[M-epiN] G[MivN] groups comparing with G[M]. Our data indicate that the addition of nalbuphine either intra venous or epidurally prevent the morphine induced side effects without reversing its analgesic effect
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Comparative Study
/
Hemodynamics
/
Anesthesia, Epidural
/
Anesthesia, Intravenous
/
Morphine
/
Nalbuphine
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Benha Med. J.
Year:
2007
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