Optic nerve metastasis from squamous cell carcinoma of the uterine cervix

ABSTRACT

Metastatic involvement of the optic nerve or its sheath is very rare [1.3 - 3%]. The most common malignancies reported to metastasize to the optic nerve or its sheath are breast, lung, kidney, bladder, gastric and colorectal cancers. Carcinoma of uterine cervix metastatic to optic nerve and optic nerve sheath is extremely rare and is associated with grave prognosis due to underlying high tumor burden. Here in, we report a 61-year Saudi woman who was treated with concurrent chemoradiation for squamous cell carcinoma of cervix FIGO IVA 6 months back. She presented with pain and progressive visual loss in the right eye. Magnetic resonance imaging showed enhanced solid mass of the intraorbital optic nerve consistent with optic nerve sheath meningioma. Immunostaining [CK5/6, CAM 5.2, p63 and p16] confirmed the diagnosis of metastatic squamous cell carcinoma of uterine cervix