T cell function: leukocyte migration inhibition [MIF] and T cell subsets in chronic liver diseases

ABSTRACT

Thirty six patients with chronic liver diseases and twenty controls with comparable sex and age were selected from outpatients clinic of general medicine, Ain Shams University Hospital. They were subjected to enumeration of total T-lymphocytes, T-lymphocyte subsets and assay of leucocyte migration inhibition factor. Results showed significant decrease in total T-lymphocytes, and T-helper lymphocytes with significant increase in T-suppressor lymphocytes. In vitro study of T-lymphocyte function showed significant decrease in MIF reflected by decrease in percentage inhibition of migration