[Comparison of the effectiveness of double IUI versus single IUI in pregnancy rate in infertility]

ABSTRACT

In infertility without suffering tubal factor, WI is the choice therapeutic method. Some studies recommended double IUI for every cycle. Since double IUI needs more laboratory materials and more expenses, so in this study it was tried to evaluate pregnancy rate in infertile couples after single and double IUI. This clinical trial study was performed on infertile couples referred to Fatemeh Alzahra or Babol Clinic hospital for IUI cycles. Patients divided into two groups. In the first group, 36 hours after HCG injection, IUI was done as a single protocol and in the other group; IUI was done 24 and 72 hours after HCG injection as double protocol. Then data were analyzed by fisher's exact test. Two hundred and fifteen women participated in our study and their mean age was 26.02 +/- 5.5 and the mean [ +/- SD] duration of infelicity was 3.73[ +/- 2.75] years. In the first group, pregnancy rate was 16.9% and in second group it was 19.6% without any significant difference between two groups. Also, there was no significant difference between groups in pregnancy rate with different etiology of infertility. Some studies recommended that double IUI is more successful than single IUI. But present findings suggest that there is no difference in pregnancy rate between single IUI and double IUI