Injection sclerotherapy and hemostatic changes in hepatic schistosomiasis patients

ABSTRACT

Fifteen adult male Egyptian hepatosplenic schistosomal patients with bleeding oesophageal varices were studied. Ethanolamine oleate was used as a sclerosant for sclerotherapy. Haemostatic laboratory tests were performed before then one day and two weeks after endoscopic injection sclerotherapy EIS. One day after EIS, tests revealed shortening of blood clotting, bleeding and prothrombin time [PT] times associated with a significant increase in factory VIII while changes in other strudied factors were mild. Platelets showed elevation of their count and improvement of their function. Moreover, fibrinogen levels were increased, euglobulin lysis time was prolonged and there was negative agglutination for fibrinogen degradation products [FDPs] in 40% of cases. Two weeks after EIS, all studied haemostatic parameters returned to their pre-injection levels. Accordingly it is suggested that EIS has both local and systemic transient haemostatic effects