effect of gundelia tournefortii hydro-alcoholic extract on sperm motility and testosterone serum concentration in mice

ABSTRACT

Gundelia tournefortii was used as a food and medicinal in human life from past time. The present study has been investigated the effects of Gundelia tournefortii on number and motility of sperms and testosterone serum concentration. In this experimental study, male mice were divided into control and 4 experimental groups [Gundelia tournefortii extract at doses of 100, 200, 400, 800 mg/kg was administered intraperitoneally for 14 days]. One week after the last injection, blood samples were collected for hormonal assay. Also weight of testes, motility rate and number of sperms were assessed. Data analysis was performed using one-way ANOVA followed by Tukey test. Studies showed the number of sperms increased significantly at dose of 400 mg/kg [2.88 +/- 0.4580] [p=0.001].The percentage of sperm motility [p=0.001] and the testicular weight [p=0.012] significantly increased at doses of 200 [36.83 +/- 1.2506] and 400 mg/kg [57.51 +/- 2.1113] [p=0.001]. Testosterone serum level significantly increased at doses of 100 [p=0.05], 200 [p=0.05] and 400 mg/kg [p=0.001] as compared to control group. Gundelia tournefortii extract increases the number, motility of sperm and testosterone level because of antioxidant components for example Quercetin presumably