Effect of biebersteinia multifida DC. root extract on cholesterol in mice

ABSTRACT

Hypercholesterolemia and atherosclerosis are the most common causes of mortality and disability, especially in developed countries. The aim of this research was to evaluate the effect of Biebersteina multifida DC. root extract on HDL and LDL blood level. In this experimental study, 35 male Balb/c mice were randomly divided in five groups such control, sham, and experimental groups which received Biebersteina multifida DC. root extract with the doses of 4, 5 and 10 mg/kg; three last groups were daily fed orally, for thirty days. HDL and LDL blood serum levels were measured, in the last day and compared with control and sham groups. The results after 30 days gavage of 4, 5 and 10 mg/kg of Biebersteinia Multifida DC. root extract showed that the root extract decrease of LDL level significantly. The doses of 4, 5 mg/kg of the root extract were the effective dose in decreasing the serum HDL level. However, 10 mg/kg dose of root extract has no significant effect on HDL level in comparison with control and sham groups. 10 mg/kg of root extract had the maximum effect on reducing LDL level. According to this study, it is suggested that the root extract of Biebersteinia multifida DC. can be efficient to reduce the level of HDL and LDL in blood serum