evaluation of psychological factor and salivary cortisol and IgA levels in patients with oral Lichen Planus

ABSTRACT

Oral lichen planus [OLP] is a chronic immunological disorder with unknown etiology. The aim of this study was to determine psychological factors and salivary cortisol, IgA level in patients with oral lichen planus. In this experimental study 20 patients with OLP and healthy person were admitted to this study. Saliva samples were collected between 9-10 Am. saliva cortisol, IgA level was detected by ELIZA method. In this study, patients with anxiety and depression were measured using the SCL-90 questionnaire. Data analyzed by t-test. The mean salivary cortisol level in patients with OLP was 3.2 +/- 1.9 ng/mL and the mean saliva cortisol level in healthy person was 3.5 +/- 1.9 ng/mL. Significant difference was observed in the salivary cortisol levels in the 2 study groups [p=0.04]. The mean salivary IgA level in patients with OLP was 0.69 +/- 0.29 ng/mL and the mean saliva IgA level in healthy person was 0.9 +/- 0.43 ng/mL but no significant difference was observed in the salivary cortisol levels in the 2 study groups. Results showed that anxiety levels in patients with oral lichen planus were slightly higher than controls but there was no significant difference between healthy subjects. Finding revealed the mean salivary cortisol level in patient with OLP less than healthy persons. Significant difference was observed in the salivary cortisol levels in the 2 study groups. Based on the t-student test, no significant difference was observed in the salivary IgA levels in the 2 study groups. Anxiety levels in patients with oral lichen planus were slightly higher than controls