relationship between serum level of manganese and severity of coronary atherosclerosis

ABSTRACT

Trace elements such as manganese have an important role in the maintenance of the normal structure and physiology of cells. Manganese is involved in many biological processes. Therefore, an evaluation of the manganese in the atherosclerotic disease is important. In this cross sectional study, 334 subjects, without recent cardiac event and history of collagen vascular or infectious disease were investigated. All patients divided into 4 groups to evaluate severity of coronary artery disease according to Syntax scoring system. All groups were matched in cardiovascular risk factors. The serum level of manganese in normal coronary group was 1.47 +/- 0.23 micro g/L and in total atherosclerotic groups was 1.06 +/- 0.37 micro g/L. The serum level of manganese was significantly lower in total atherosclerotic groups than normal group [p=0.001] and significantly decreased with severity of atherosclerosis. The serum level of manganese was significantly lower in sever atherosclerosis patients than mild and moderate coronary artery disease groups [p=0.001]. The finding indicated that the serum level of manganese is lower in atherosclerotic patients and it decreases with severity of atherosclerosis