Methotrexate and misoprostol against misoprostol alone for early medical abortion: comparative study

ABSTRACT

Vaginal mifepristone oral misoprostol have proven to be highly effective medical abortion methods and are used widely in in modern countries. The objective of this study is to compare the efficacy for two medical abortion regimens used in one clinic setting misoprostol alone, intramuscular methotrexate and vaginal misoprostol. An intervention study was conducted on a total of 100 randomly selected women with gestations of first-trimester pregnancy, who sought a missed abortion. Study population was assigned as two groups, the first was subjected to vaginal administration of Misoprostol and the second was subjected to EV1 injection of methotrexate and self-administration of vaginal misoprostol After 72h. All patients were followed up for recording any side effects of the drugs, progress of abortion and if there was any need for surgical interference [manual vacuum aspiration [MVA] or dilatation and curettage. Success rate of the methotrexate regimen was 80% and did not differ significantly from the misoprostol regimen that had success rate of 84%.In this real-use setting, the use of misoprostol in combination with methotrexate or alone for the missed abortion termination are both safe and effective methods without serious side effects