association study on IL16 gene polymorphisms with the risk of sporadic alzheimer's disease

ABSTRACT

Interleukin-16 [IL-16] is an important regulator of T cell activation and was reported to act as a chemoattractant agent. There are evidences that IL16 can control the neuroinflammatory processes in Alzheimer's Disease [AD]. This study was performed to investigate the role or association of IL16 polymorphisms, rs11556218 and rs4778889 with the risk of late-onset Alzheimer's disease [LOAD] in Iranian population. Totally, 148 AD patients and 137 nondemented and age-matched subjects were recruited in this study. Genotyping of rs11556218 T/G and rs4778889 T/C polymorphisms was performed by PCR-RFLP method using the NdeI and AhdI restriction enzymes, respectively. Statistical analysis of rs11556218 genotypes showed a protective effect against AD in the heterozygote genotype [p=0.001, OR=0.16] as well as rs4778889 [p=0.001, OR=0.23]. Frequency of rs11556218 allele T was higher in controls than patients [p= 0.001, OR=0.32]. However, there was no significant difference in the frequencies of rs4778889 alleles between the AD patients and controls. Our results indicate that the rs11556218 and rs4778889 polymorphisms have a protective role in the development of sporadic AD in Iranian population