effect of 12 weeks aerobic exercise on DHEAso4, 17OH-Progestron concentrations, number of follicles and menstrual condition of women with PCOS

ABSTRACT

The effective method of treatment of Polycystic Overy Syndrome [PCOS] is lifestyle modification. The aim of this study was to evaluate the effect of 12 weeks aerobic exercise on DHEAso4, 17OH-Progestron Concentrations, number of follicles and menstrual condition of women with PCOS. In this clinical trial, 40 PCOS patients lean [BMI<20] and obese [BMI>25] randomly divided into two trained and sedentary control groups. DHEAso4, 17OHProgestron Concentrations, number of follicles and menstrual condition were measured before and after the program [12-week exercise training program, aerobic exercise at 60-80% of maximal heart rate, 25-30 min/day, 3 days/week]. Decline of DHEAso4, 17OH-Progestron Concentrations were significant after exercise in obese group [P=0.023, P<0.0001]. The number of follicles right and left ovaries decreased significantly after exercise in two groups lean and obese [Right; P=0.019, P=0.041 and Left ovary; P=0.005, P=0.008]. Menstrual situation was improved after exercise in obese and lean groups [P=0.028, P<0.0001]. The body weight decreased significantly after exercise in obese groups [P<0.0001]. It seems that a term of exercise with weight loss can induce decline of DHEAso4 and 17OH-Progestron. In addition, exercise lead to improved menstrual condition and reduction of number of ovarian follicles per groups of lean and obese