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prophylactic role of ginger on the pulmonary injury induced by azathioprine on adult male rats [light and scanning electron microscopic study]
Assiut Medical Journal. 2013; 37 (2): 217-228
in English | IMEMR | ID: emr-170213
ABSTRACT
Azathioprine is one of the most commonly prescribed immunosuppressive drugs. It is commonly used in the treatment of the immune-mediated diseases. Pulmonary toxicity has been reported as one of its side effects. Ginger [Zingiber officinal roscoe], is a well-known spice plant that has been used traditionally in a wide variety of diseases as cardiovascular disorders, diabetes mellitus and gastrointestinal health. A study of the possible protective role of ginger on the azathioprine induced pulmonary injury in the adult male albino rats using light and scanning electron microscopy. Thirty male adult albino rats were used in the study. They were subdivided into three groups. Each group includes 10 rats. First group was considered as a control, Second group was given azathioprine in a dose of 25 mg/kg body weight twice daily for two days. The third group was given ginger 250 mg orally per kg body weight daily for 5 consecutive days then given azathioprine drug orally for another two days in the same dose as the second group. At the end of the experiment the animals were anaethetized, sacrified and specimens of the lung tissues were extracted and processed to he examined with light and scanning electron microscopy. In group 11, there were thickness of interalveolar septa, lymphocytic cellular infiltration and narrowing of alveolar sacs by light microscopy while in scanning electron microscopy there was thickening of interalveolar septa with narrowing of alveolar sacs, loss of microvilli and laceration of type 11 pneumocytes, disorganized cilia of terminal bronchioles. In group 111 the effect of azathioprine was less than that of group 11 there was less narrowing of the alveolar spaces, less cellular infiltration both type 1 and type 11 pneumocytes and Clara cells were nearly similar to those of control. Administration of ginger prior to azathioprine therapy had a protective effect against the pulmonary injury induced by azathioprine on adult male rats
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Index: IMEMR (Eastern Mediterranean) Main subject: Microscopy, Electron, Scanning / Treatment Outcome / Protective Agents / Ginger / Lung / Antimetabolites Limits: Animals Language: English Journal: Assiut Med. J. Year: 2013

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Index: IMEMR (Eastern Mediterranean) Main subject: Microscopy, Electron, Scanning / Treatment Outcome / Protective Agents / Ginger / Lung / Antimetabolites Limits: Animals Language: English Journal: Assiut Med. J. Year: 2013