CD[95] as an early and sensitive marker of neonatal sepsis and disease outcome

ABSTRACT

This study was carried out on 33 neonates. They were classified into 2 groups the first group included 18 septic neonates [9 males and 9 females] of these 11 were fullterm and 7 were perterm. The second group included 15 healthy neonates as a control group [7 males and 8 females] of these 10 were full term and 5 were preterm. All cases and controls were subjected to thorough history, clinical examination, laboratory investigation for both groups included complete blood picture, total and differential leucocytic count, erythrocyte sedimentation rate [ESR], c-reactive protein [CRP], blood culture in septic cases and Fas /Apo 1 / CD[95]. The level of CD[95] is significantly elevated in septic full term and septic preterm compared to normal full term and normal preterm respectively [both P<0.0001]. Comparing CD[95] levels in septic neonates according to the severity of infection there was significant difference between cases who recovered and those who died [P<0.05]. There was no significant correlation between the levels of CD[95] in septic cases and the causative organism. Comparing CD[95] with other laboratory results, there was significant negative correlation between CD[95] levels and platelet count, significant positive correlation with total leucocytic count in septic full term and negative correlation in septic premature. There was also positive correlation between CD[95] level and CRP. In conclusion, soluble CD[95] can be used as an early and sensitive marker in diagnosis of neonatal sepsis