[Studying thrombotic markes in chronic periodontitis with hypertension]

ABSTRACT

Recent studies has focused on the impact of periodontal disease on the general health like cardiovascular disease and hypertension and their interactions. We aimed to study several vascular thrombotic markers levels in patients with chronic periodontitis and hypertension. Study population consisted of 80 patients aged 30- 68 years, [mean 43.7 years], [53 males, 27 females], were divided into 2 groups; the first, [n=40], had only chronic periodontitis, and the second,[n=40], were hypertensives with chronic periodontitis. Registrations included systolic blood pressure] [sBP], body mass index[BMI], and periodontal disease indices; dental plaque [PI], gingival inflammation [GI], bleeding on probing [BOP], and clinical attachment loss [CAL] Blood tests included; platelets count [Plt], fibrinogen [Fib], prothrombin time [PT], activated partial thromboplastin [aPTT], and Von Willebrand factor antigen [vWFAg]. Independent T-test and Pearson correlation, were performed at [P<0.05] by means of SPSS 19th ed. Hypertensives with periodontitis showed higher significant differences in age [P=0.001], [sBP] [P=0.001], [FBG] [P=0.001] [Plt] [P=0.022], [Fib] [P=0.001], and in [PPD] [P=0.008], [CAL] [P=0.001]. Significant moderate positive correlation was found between [Plt] and both of [PPD] and [CAL], while [Fib] correlated with[CAL], [r= 0,3- P<0.05]. Periodontitis in hypertensives was associated with an elevation in platelets count and fibrinogen concomitantly with an increase in blood glucose levels and body mass index,in addition to greater pocket probing depth and clinical attachment loss, compared with periodontitis only.These results shed the light on periodontitis as a risk indicator for hypertension and thrombotic propensity in susceptible individuals