[Assessing the role of rat's orbitofrontal cortex on sleeping time andduration]

ABSTRACT

Sleeping is a biological rhythm controlled by many structures and neurotransmitter systems in brain. Previous evidences suggested that Orbit frontal Cortex [OFC] is probably involved in sleeping time and the duration. The aim of this study was to determine the role of OFC area in duration and the time of sleeping by electrical lesions. Male Wistar rats were used in this experimental study. Rats were surgically implanted bilaterally guided cannulae aimed at the OFC by stereotaxic instrument. One week after recovery, a primary assessment of sleeping duration was made by Angel behavioral method followed by lessoning of OFC using lesion-maker [electrical electrode]. Measuring the behavioral manifestations continued for time and the sleeping duration. The data found in our study was indicative of a significantly increased sleeping time [P<0.01] following the electrical lessoning of OFC. Our findings showed that OFC of rat's brain may play an important role in regulating the sleeping process