Effect of ascorbic acid on the hepatic and renal toxicity of some aminoglycoside antibiotics

ABSTRACT

The effects of i.p. injections of aminoglycoside antibiotics Amikacin, gentamicin and tobramycin in doses of 70, 35 and 35 mg/kg respectively for 10 consecutive days and their combination with ascorbic acid [250 mg/kg, orally] on liver and kidney functions of rabbits were studied. Treatment with aminoglycoside antibiotics revealed slight increase in serum proteins [S.prot], serum alanine aminotransferase [S. ALAT] and serum alkaline phosphatase [S. APHOS] values. On the other hand, combination between aminoglycoside antibiotics and ascorbic acid reduced significantly serum urea and serum creatinine levels, but the reduction was not significant in case of amikacin with ascorbic acid compared with amikacin treated group. The present work revealed that ascorbic acid has a protective effect against the aminoglycoside antibiotics induced nephrotoxicity