Comparative adverse effects of low-dose oral prednisolone and oral mini pulse dexamethasone in patients of vitiligo
JPAD-Journal of Pakistan Association of Dermatologists. 2015; 25 (1): 23-29
in English
| IMEMR
| ID: emr-171485
ABSTRACT
To compare the adverse effects of low-dose oral prednisolone and oral mini pulse dexamethasone in patients of vitiligo. A clinical trial was carried out from January 2013 to December 2013. Total sixty patients of vitiligo were enrolled and 30 of group A patients were treated with low dose oral prednisolone [0.3 mg/kg body weight] daily and 30 of group B patients were treated with oral dexamethasone pulse therapy [10 mg per week] for 16 weeks. During 12 week follow-up, increased body weight, headache, dyspepsia and fatigue were more frequent in group A as compared to group B. Similarly, in group A other side effects noted were acne [33.3%], mooning of face [26.6%], striae [26.6%], hypertrichosis 13.2%, purpura [6.7%] and among the female patients, menstrual abnormality [71.4%] whereas in group B, no patient developed these problems from baseline to follow-up period [p<0.05] Low dose oral prednisolone was found to be associated with more adverse effects than oral dexamethasone pulse therapy in treating vitiligo
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Dexamethasone
/
Prednisolone
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
J. Pak. Assoc. Dermatol.
Year:
2015
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