Leprosy: type 1 reaction precipitated by doxorubicin and cisplatin
JPAD-Journal of Pakistan Association of Dermatologists. 2015; 25 (1): 55-57
in English
| IMEMR
| ID: emr-171491
ABSTRACT
Type 1 reaction [T1R] in leprosy is common and characterized by increased inflammation in skin lesions or nerve. Besides antileprotic therapy, T1Rs are associated with intercurrent infection, pregnancy and drugs. Also, T1Rs may be a presenting feature of leprosy. We report a case of T1R in leprosy presenting as drug reaction during cancer chemotherapy with doxorubicin and cisplatin. We propose to explain this unusual occurrence by highlighting the increased production and expression of TNF-alpha by these drugs. Thus, physicians using these drugs should keep this unusual adverse effect in mind
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Adenocarcinoma
/
Doxorubicin
/
Tumor Necrosis Factor-alpha
/
Cisplatin
/
Leprosy
/
Antineoplastic Agents
Type of study:
Case report
Limits:
Female
/
Humans
Language:
English
Journal:
J. Pak. Assoc. Dermatol.
Year:
2015
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