Serum uric acid levels are elevated in patients with diastolic dysfunction and preserved ejection fraction

ABSTRACT

Elevated uric acid levels are associated with diastolic dysfunction in chronic heart failure patients. Uric acid is a marker of impaired oxidative metabolism and is correlated with endothelial function. In this study, we investigated whether uric acid levels correlate with the degree of left ventricular diastolic dysfunction [LVDD] in patients with normal ejection fraction. Prospective case-control study Uric acid levels were measured in 201 patients with normal ejection fraction. The study population was divided into two groups as controls and patients with LVVD. Patients with LVDD were divided into two groups according to dysfunction grade. [Normal, n = 64, Grade 1 LVDD, n = 74, Grade 2 LVDD, n = 63]. Interventions: For uric acid analysis, 5 ml of venous-blood was drawn from each patient after at least 8 hours of fasting. Serum uric acid levels were measured and LVDD was assessed by transthoracic echocardiography normal diastolic function group than grade 1 LVDD and grade 2 LVDD groups respectively [4.28 +/- 1.20 mg/dl, 8.17 +/- 2.12 mg/dl, 9.52 +/- 2.30 mg/dl, p < 0.001]. Although Grade 2 LVDD patients had higher uric acid levels, there is no. Our study demonstrated that uric acid dysfunction. Further studies are needed to assess whether inhibition of xanthine oxidase [XO] with allopurinol results in an improvement in diastolic dysfunction