Experimental study of the effect of opioid agonists on histamine release

ABSTRACT

The aim of the present work is to investigate the histamine releasing activity of the relatively new opioid analgesic butorphanol comparing it with other opioid analgesics choosing morphine as a parent of the most opioids. The results of our study suggest that butorphanol compared to morphine has no histamine releasing activity however, it could produce a spasmolytic effect. Butorphanol is much more superior opioid having the advantages and lacking disadvantages of morphine and other opioids and can be safer in asthmatic subjects when opioid alkaloids are indicated