Protective role of oleuropein against acute deltamethrin- induced neurotoxicity in rat brain

ABSTRACT

Deltamethrin [DM] is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to apoptosis. There is accumulating evidence that oleuropein [OE] has anti-apoptotic effect. The purpose of this study was to determine the anti-apoptotic effect of OE pretreatment in the neuronal cells of cerebral cortex. Rats were randomly divided into four groups each containing five rats DM-treated group [12.5 mg/kg, a single dose], OE-treated group [20 mg/kg per day], DM + OE-treated group, and vehicle group. Sections of the brain were obtained 24 hours after DM injection and studied for histopathological and immunohistochemistry assessment. The histopathological assessments showed lesser characteristics of neural degeneration in DM + OE group compared with DM group. Greater Bcl-2 and attenuated Bax expression could be detected in the DM + OE treatedmice compared with DM group. The results suggested that DM-induced neurotoxicity can be subsided by OE