HBV serological markers versus clinico-biochmical, and histopathological evidence of activity in the evaluation of cirrhotic patients group A Child's Classification with hematemesis and/or melena

ABSTRACT

One hundred and five [105] patients with bilhazial hepatic fibrosis and/or cirrhosis fullfiling the criteria of group A child's classification were subjected to thorough clinical examination, biochemical investigation and serological determination of Hepatitis B virus markers. Moreover an upper GIT endoscopy and liver biopsy were done for every patient in the studied group. From the present work hepatitis B serologic markers alone or in combination were present in 86/105[81.9%] of cirrhotic patients group A child's classification The prevalence of each hepatitis B virus serological markers among this group of patients wasHBs AG 18/105 [17.1%], anti-HBs 26/105 [24.8%], anti -HBC IgM 1/105[22.9%] None of the hepatitis Bvirus serological markers was detected in 19/105[18.1%]. HBV serological markers profile of past infection was detected in 21/105 [20%], HBV serological markers profile of chronic current infection in 56/105 [53.3%] and HBV serological markers profile of a recent current infection in 9/105 [8.6%] of cases. Pure bilharzial hepatic fibrosis accounted for 17/105[16.2%] of cases only, mixed cirrhosis for 26/105[24.8%], pure posthepatitic, most likely, due HBV infection in 53/105[50.5%], and undetermined etiology in 9/105[8.6%], of cases. According to the accepted criteria of active cirrhosis, 16.26[61.5%] patients with mixed cirrhosis and 10/53[18.7%] patients with pure cirrhosis showed biochemical and histopathological evidence of active cirrhosis thus we have assured a total incidence of active cirrhosis in 26/105[24.8%] of this group of patients