Anti-inflammatory and antinociceptive activity of stem juice powder of Tinospora cordifolia Miers in experimental animals

ABSTRACT

The stem juice powder of Tinospora cordifolia Miers. [Menispermaceae, TIP] was studied for the possible activity of anti-inflammatory and antinociceptive to rationalize the folkloric use of the plant juice as rasayana. TIP at the dose of 50-200 mg/kg caused a significant and dose dependent inhibition of swelling caused by the X carrageenin [1%] and histamine [10-3 g/ ml, 0.1 ml] induced paw edema in rats. The effect was comparable to the standard cycloxygenase inhibitor Ibuprofen 100 mg/kg and percent protection was 18.43% and 18.12% respectively. Administration of TJP [50-200 mg/kg] on analgesy-meter induced mechanical pain exhibited a moderate and dose dependent increase in the pain threshold. However TJP significantly prevented the pain reaction in acetic acid [0.6%] induced writhing in mice and the degree of percent inhibition was 16.98%-35.47%, which is equivalent to 36.67% produced by ibuprofen. These data indicate that the stem juice powder of Tinospora cordifolia rationalizes the traditional system of medicine