Effect of interaction between furosemide and oxytetracycline on blood urea and creatinine in rats

ABSTRACT

Since some workers reported that paracetamol can antagonize the toxic effect of aspirin on the gastric acidity in rats, the present work was done to study the effect of paracetamol on the analgesic and anti- inflammatory activity of aspirin in rats. It was found that the anti- inflammatory effect of paracetamol and aspirin additive. Although antagonism was observed in the analgesic test, the effect of the combination was not inferior to that of paracetamol alone. In light of the present study and reports of other workers on experimental animals, it may be concluded that although paracetamol antagonized the analgesic effect of aspirin, yet the protection which paracetamol offer against gastric damage produced by aspirin make the combination of both drugs might be of value in antirheumatic therapy