Congential t-cell immunodeficiency with post BCG systemic TB infection

ABSTRACT

Objectives and important to report a case of congenital T-ceIl immunodeficiency with post BCG vaccination systemic TB infection. clinical presentation 6 months old infant presented by respiratory symptoms, light coma, FTT and HSM. Initial investigation CXR showed miliary opacities in both lungs, abdominal U/S showed hepatosplenomegally [HSM] with homogenous echogenicity. CT brain W out contrast showed ventricular dilatation and encephalomalacia and brain distortion, immunological study showed total immunoglobins and IgG, IgM, IgA, IgD, IgE were within normal range. T-lymphocytes showed decrease in total lymphocytes and decease in T4 [T-helper] T8 [T-suppressor] NK [Natural killer] suggests T-cell immunodeficiency. CBC showed microcytic hypochromic anemia[HB 8.5gm/dl] anemia of chronic illness, Screening for IIIV infection negative