Study of soluble intracellular adhesion molecule-1[s1CAM-1] as a laboratory marker for grading hepatic fibrosis in patients suffering from schistosomiasis mansoni

ABSTRACT

Chronic schistosomiasis mansoni is a serious disease that ends by periportal fibrosis with various degrees. In the present work, finding serum sICAM-1 level as an accessible laboratory method to measure the degree of pathogenecity was done to cases with different stages of Schistosoma mansoni infection. Different degrees of pathogenecity was first assessed by kato-Katz stool examination in-group I and ultrasonographic grading of periportal fibrosis in group II By sonagraphic grading, patients in group II were classified to grade I [incipient fibrosis], grade II [moderate] and grade Ill [severe] fibrosis. Results of the present work revealed high significant increase of sICAM-l serum level [P<0.005]from grade I [incipient periportal fibrosis] to grade III [serve fibrosis]. Positive correlation [R= 0.65] between portal vein diameter and sICAM-l level was also detected. These findings could suggest serum level of sICAM-1 as a good laboratory indicator for grading hepatic peripotal fibrosis in parallel with sonography in a patient suffering from chronic schistosomiasis mansoni