Renovascular protective effects of the angiotensin converting enzyme inhibitor "Ramipril" and the angiotensin receptor blocker "osartan" on experimentally diabetic rats

ABSTRACT

Diabetes mellitus is one of the most common diseases in the world. It has the potential to cause many complications such as increased blood pressure, disturbance in the kidney functions and elevation of blood lipids.. The aim of the present work was to evaluate the possible renal and vascular protective effects of the angiotensin converting enzyme inhibitor [ACEI], ramipril, as well as the selective angiotensin II receptor blocker [AIIRB], losartan, and the combination of both drugs in diabetic rats. We used 50 rats divided into 5 groups control, diabetic control and three other diabetic groups each was treated by one of the described drug regimen. Systolic blood pressure, blood glucose, renal function tests, lipid/profile and histopathological examinations were performed to all the groups. Our results revealed that after'6eeks of treatment with rarnipril, losartan, and ramipril plus losartan, there was a significant decrease in the systolic blood pressure [SBP]. When we analyzed the obtained data, we found that the described drug groups had a renoprotective effects in diabetes meilitus. In addition, there were significant decrease in serum triglyceride, and low density lipoprotein [LDL], while serum high density lipoprotein [HDL] was increased as compared with diabetic control group. However, the intensity of changes produced by losartan was of greater extent than that produced by ramipril. The combination of ramipril plus losartan proved to be superior on the two other separate drugs