Effect of passive smoking and familial essential hypertension on vitamins and lipid profiles in children

ABSTRACT

In this study we examined the effect of passive exposure of children with a family history of essential hypertension [CFHEH] to tobacco, on the lipid profite, vitamin E [Vit. E] and vitamin C [Vit. C]. This study was carried out on 39 passive smoker children of fathers with essential hypertension of both sexes [18 females and 21 mates], their ages ranged from 8-13 years. A group of 15 healthy children [7 females and 8 males] with the same age range and with no history of any disease was included as control group. Serum total lipids, triglycerides, cholesterol, high density Iipoproteins [HDL], low density lipoproteins [LDL], Vit, E and Vit, C were estimated in serum. A highly significant decreased in the levels of serum Vit. C and Vit. E [0.2 micro g/dt +/- 0.3 11 and 2.45 mg/dl +/- 0.152], respectively as compared to the control children [0.291 pg/dl +/- 0.113 and 3.491 mg/dl +/- 0.141], a significant increase in serum level of triglycerides and cholesterol in passive smoking children of fathers with family history of essential hypertension [250.34 mg/dl +/- 2.345 and 180,5 mg/dl +/- 3.45], respectively, as compared to the control children [152.75 mg/dl +/- 4.61 and 80.794 mg/dl +/- 4.9], respectively. No significant changes in the level of total lipids and HDL-cholesterol in passive smoking children of fathers with familial hypertension [589.833 mg/dl +/- 12.5 and 69.941 mg/dl +/- 5, 34], respectively, as compared to the control children [558.47 mg/dl +/- 13.8 and 63.333 mg/dl +/- 4.5], respectively. fidso, a significant increase in LDL-cholesterol in passive smokers of children of fathers with familial hypertension [52,323 mg/dl +/- 3.42] as compared to control children [31.666 mg/dt +/- 2.5]. It was concluded that passive smoking and a positive family history of essential hypertension are important risk factors for cardiovascular diseases