Predictive value of c-reactive protein for coronary in stent restenosis

ABSTRACT

C-Reactive protein [CRP] should be measured in all patients undergoing coronary angioplasty for prognostic stratification. Preprocedural levels are of proved efficacy. CRP levels can be used as a guide to therapy in PCI. The aim of this study is to evaluate the predictive value of CRP plasma leve1 for coronary instent restenosis [ISR]. This study included 60 patients who underwent successful coronary stenting. All patients included in. this study were subjected to the following. Full history taking, thorough clinical examination, risk factors evaluation, 12 leads surface ECG, plain chest x-ray echocardiography, coronary angiography and laboratory investigations [Blood sugar level lipid profile and CRP] with follow up period for six month. Patients were classified into two groups according to ISR. Group [I] with ISR included 22 patients [43.1%] and 22 lesions treated with 25 stents [45%]. Group [II] without ISR included 29 patients [59.9%] with 29 lesions treated with 30 stents [55%]. At follow up, focal ISR [<10 mm] was detected in 5 patients [22.7%]. diffuse [>10 mm] in 7 patients [31.8%], proliferative ISR in 5 patients t22. 7%] and total occlusion in 5 patients [22.7%]. In restenotic group [I] 8 patients [36.4%] were asymptomatic, two p [9.1%] had unstable angina and 12 patients [54.5%] had stable angina. In the non restenotic group [II] 22 patients [75.9%] were asymptomatic four patients [138%] had unstable angina and three patients [102%] had stable angina. Clinical, lesional and procedural variables are not associated with in creased risk of ISR. The only variable for exclusion of ISR was a normal level of CRE in plasma [72 hours after coronary stenting]. Its specificity was [100%]