Study of the pathophysiological mechanism in patients with typical chest pain and normal coronary arteries
Benha Medical Journal. 2004; 21 (1): 607-628
in English
| IMEMR
| ID: emr-172768
ABSTRACT
Endothehelial dysfunction. thrombogenesis and inflammation were studied as possible mechanisms in pathogertesis of cardic syndrome-X through monitoring plasma endothelin-1 fibrinogen, vWF and CRP in patients with typical chest pain, positive stress ECG[clinical and ECG evidence of ischemia] and normal coronary angiography. The aim of this study is to evaluate plasma concentration of enclothelin-1 and other factors in patients with typical angina pectoris and angiographically normal coronary arteries. This study included 50 patients complained of typical chest pain [group A], Another group of 20 healthy subjects were studied as control group [group B]. Exercise test and coronary angiography were performed for all patients. Patients showing positive exercise ECG and having normal coronary arteries were selected. Blood samples were collected and examined for endothelin-1, fibrinogen, CRP and vWF. Endotheline-l fibrinogen, CRP and vWF were found to be significantly raised in that group of patients with syndrome-X in comparison with the control group, so they could predict and confirm diagnosis in patients with syndrome-X. CRP, vWF fibrinogen and ET-1 in that order were significantly high in patients with syndrome-X. Thus assessment of their levels in serum may be highly needed to fulfill the diagnosis of cardiac syndrome-X
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
C-Reactive Protein
/
Fibrinogen
/
Von Willebrand Factor
/
Angiography
/
Microvascular Angina
/
Endothelin-1
/
Coronary Vessels
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Benha Med. J.
Year:
2004
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