[Association of 1082G/A estrogen receptor genes polymorphisms with recurrent abortions using AS-PCR]

ABSTRACT

Background and Aim: Abortion is spontaneous termination of pregnancy before the 20[th] week. Recurrent pregnancy loss [RPL], also referred to as recurrent miscarriage or habitual abortion, is historically defined as 3 consecutive pregnancy losses. There are several known risk factors associated with recurrent miscarriages, including genetic, endocrine, autoimmune, anatomical. Causes of recurrent miscarriages in 50% of the cases remain unexplained. It has been hypothesized that genetic polymorphism in estrogen receptor genes would be associated with recurrent miscarriages