Chronic myeloid leukemia with rare e1a3 BCR-ABL transcript
Pakistan Journal of Medicine and Dentistry. 2015; 4 (1): 52-53
in English
| IMEMR
| ID: emr-173597
ABSTRACT
Chronic myelogenous leukemia [CML] results from neoplastic transformation of a hematopoietic stem cell. It is cytogenetically characterized by the presence of Philadelphia chromosome which results from reciprocal translocation t[9;22] that juxtaposes the ABL gene on chromosome 9 with breakpoint cluster region [BCR] on chromosome 22 generating BCR-ABL oncogene. All BCR-ABL fusion proteins display activated tyrosine kinase activity. Their different types are associated with different clinical course and prognosis. We report a rare case of e1a3 BCR-ABL transcript. So far only 4 cases in patients with CML have been reported
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Pak. J. Med. Dent.
Year:
2015
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