IFN-stimulated genes upregulation pattern in Chronic Hepatitis C
Egyptian Journal of Hospital Medicine [The]. 2015; 61 (October): 389-405
in English
| IMEMR
| ID: emr-173897
ABSTRACT
Background:
The development of effective tools for the large-scale analysis of gene expression has provided new insights into the involvement of gene networks and regular pathways in various disease processes. The chemokine receptor CXCR3 is a G protein-coupled receptor found predominantly on T cells that is activated by three ligands as follow CXCL9 [Mig], CXCL10 [IP-10] and CXCL11 [I- TAC], and play a key role in immune and inflammatory responses by promoting recruitment and activation of different subpopulations of leukocytes. Aim of the work The study is a logical functional approach for the development of serum markers chemokines that bind to CXC chemokine receptor 3 to determine whether they play a role in the future of immune system to clear HCV, these chemokines CXCL9, CXCL10 and CXCL11
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Up-Regulation
/
Chemokines
/
Chemokine CXCL9
/
Chemokine CXCL10
/
Chemokine CXCL11
/
Receptors, CXCR3
/
Genes
/
Immune System
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Egypt. J. Hosp. Med.
Year:
2015
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