Homocysteine as a risk factor in coronary heart disease

To study Homocysteine as a risk factor in coronary heart disease [CHD] patients. Design: Cross sectional observational study. All the cases taken from 1st November 2002 to 31st October 2003 were included in the study from the Department of Cardiology, KRL Hospital Islamabad. Total 93 subjects below the age of 45 were taken. Thirty normal healthy subjects [group I], remaining 63 Myocardial Infarction patients were further divided into two groups, 33 cardiac and non diabetic subjects [group II], 30 cardiac and diabetic subjects [group III]. Biochemical analysis include Serum Cholesterol, Glucose, Lipid Profile and Homocystene levels. The data about total Serum Cholesterol, TG,HDL, Homocystens level was analyzed in all three groups and studied in tabulation, cross tabulation and SPSS was applied for significance. The mean values of homocystene in groupl [normal healthy subjects] is 12.3 +/- 1.46 in group2 [cardiac and non diabatic] 14.3 +/- 4.09 and in groups [cardiac and diabatic] is 15.1 +/- 4.8. Homocystene was found raised in group3 as compared with groupl and group2. High levels of Homocysteine is a risk factor in CHD