Pattern of MRI brain in neuro-psychiatric SLE. effect of anti-phospholipid antibodies: a study at a tertiary care teaching hospital

ABSTRACT

To compare the neuro-radiologic findings in Systemic lupus erythematosus [SLE] patients with and without antiphospholipid antibodies [aPL] in different neuro-psychiatric manifestations. This cross-sectional comparative study was carried out at King Khalid University Hospital, a tertiary care teaching hospital, Riyadh, Saudi Arabia from June 2012 to January 2015. Ninety seven SLE patients with neuro-psychiatric manifestations were included in the study and divided into two groups. Group I [50 patients] SLE with aPL and group II [47 patients] SLE without aPL. We compared Demographic features, clinical manifestations and magnetic resonance imaging [MRI] brain findings. Demographic and clinical characteristics of two groups were similar. In Group-l, anticardiotipin antibodies [aCL] were most common [86%]. In patients with headache, most of the patients in Group-l had white matter hyperintensities [WMHIs] [50% vs 27%] while most of the patients in Group-ll had normal MRI brain [38% vs 73%]. Similarly WMHIs were found more in Group-l patients with seizures [60% vs 21%], while ischemia/infarction, atrophy and normal MRI were found in Group-ll. MRI brain in patients with neurological deficit and psychiatric disorder were not much different in both the groups. We found no statistically significant differences in frequencies of MRI brain abnormalities in SLE patients with and without aPL antibodies. Each of the three aPL may have a variable effect on the brain