Non hodgkin's lymphoma - a study

ABSTRACT

The objective of the study was to determine the frequency and pattern ofNon Hodgkin's lymphoma [NHL] in adults in a tertiary care hospital. This retrospective study was conducted at Histopathology Department, Dr. Ziauddin Hospital over a period of 09 years, from 2003 to 2011. 192 cases ofNon Hodgkin's lymphoma [NHL] were retrieved from surgical pathology record. After routine H and E stain examination, a panel of immunohistochemical stains was applied on formalin fixed paraffin embedded tissue. The data was analyzed for type of lymphoma, age and sex distribution, site of biopsy and immunophenotypic features. Out of 192 cases ofNon Hodgkin's lymphoma [NHL], 132 [69%] were males and 60 [31%] were females. Mean age of patients was 46.7 years and median age was 47 years. B cell lymphoma was out numbered [87%] than T cell lymphoma [13%]. Diffuse large B-Cell lymphoma was the commonest [113] B cell lymphoma followed by other types of lymphoma. 52% cases were from extra nodal sites followed by 34% of nodal lymphoma. Site of biopsy was not mentioned in 14% cases. In adults, B cell Lymphoma is more frequent than T cell Lymphoma with Diffuse large B-cell lymphoma being the commonest Non Hodgkin's Lymphoma