Modulation of lipopolysaccharide stimulated nuclear factor kappa b mediated inos/no production by bromelain in rat primary microglial cells
IBJ-Iranian Biomedical Journal. 2016; 20 (1): 33-40
in English
| IMEMR
| ID: emr-174275
ABSTRACT
Background:
Microglial cells act as the sentinel of the central nervous system. They are involved in neuroprotection but are highly implicated in neurodegeneration of the aging brain. When over-activated, microglia release pro-inflammatory factors, such as nitric oxide [NO] and cytokines, which are critical in eliciting neuroinflammatory responses associated with neurodegenerative diseases. This study examined whether bromelain, the pineapple-derived extract, may exert an anti-inflammatory effect in primary microglia and may be neuroprotective by regulating microglial activation.
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Iran. Biomed. J.
Year:
2016
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