Study of prevalence and effects of insulin resistance in patients with chronic hepatitis C genotype 4
EMHJ-Eastern Mediterranean Health Journal. 2015; 21 (11): 803-810
in English
| IMEMR
| ID: emr-174802
ABSTRACT
There is strong epidemiological evidence linking hepatitis C virus [HCV] infection and diabetes. Our aim was to evaluate the prevalence of insulin resistance in Egyptian patients with chronic HCV genotype 4 infection, to assess factors associated with insulin resistance and to test the impact of insulin resistance on outcomes of treatment with pegylated interferon/ribavirin. Insulin resistance [homeostasis model assessmentinsulin resistance [HOMA-IR] score > 3.0] was detected in 31 of 100 nondiabetic patients. The relationship between elevated HOMA-IR and baseline viral load and degree of fibrosis was statistically significant [r = 0.218 and r = 0.223]. Follow-up of patients with complete early virological response until the end of treatment showed a statistically significant decrease in HOMA-IR score. Out of 29 liver tissue sections examined, 14 had a low level of expression of insulin receptor type 1 by immunohistochemical studies. This study confirms that insulin resistance affects treatment outcome, and thus HOMA-IR testing before initiation of therapy may be a cost-effective tool
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Patients
/
Prevalence
/
Hepatitis C, Chronic
/
Genotype
Type of study:
Prevalence study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
East Mediterr Health J.
Year:
2015
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