Association between thyroid hormone levels and insulin resistance and body mass index
Pakistan Journal of Medical Sciences. 2015; 31 (6): 1417-1420
in En
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| ID: emr-175119
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Objective: Previous studies have shown an association between thyroid function and insulin resistance and obesity. We compared insulin resistance and body mass index [BMI] in patients with normal TSH levels [2.5-4.2 microIU/mL], patients diagnosed with subclinical hypothyroidism, and healthy control subjects
Methods: The study included 104 subjects and was conducted at the Taksim Education and Research Hospital. The subjects were divided into three groups according to TSH levels: Group 1 [high-normal], TSH levels were 2.5-4.2 microIU/mL [n=33]; Group 2 [subclinical hypothyroidism], TSH levels were 4.2-10 microIU/mL [n=42]; and Group 3 [healthy control], TSH levels were 0.27-2.5 microIU/mL [n=29].The fT3 and fT4 levels were within normal limits in all groups. Insulin resistance and BMI were compared among groups. The homeostasis model assessment of insulin resistance [HOMA-IR] was used to estimate insulin resistance
Results: HOMA-IR and BMI were not significantly different among groups [p>0.05]. A significant positive correlation was found between BMI and HOMA-IR in the high-normal TSH [p>0.059] and subclinical hypothyroidism [p>0.05] groups
Conclusions: HOMA-IR and BMI are important for the assessment of diabetes and cardiovascular diseases. We found no significant difference in HOMA-IR and BMI values among the three TSH reference range groups
Methods: The study included 104 subjects and was conducted at the Taksim Education and Research Hospital. The subjects were divided into three groups according to TSH levels: Group 1 [high-normal], TSH levels were 2.5-4.2 microIU/mL [n=33]; Group 2 [subclinical hypothyroidism], TSH levels were 4.2-10 microIU/mL [n=42]; and Group 3 [healthy control], TSH levels were 0.27-2.5 microIU/mL [n=29].The fT3 and fT4 levels were within normal limits in all groups. Insulin resistance and BMI were compared among groups. The homeostasis model assessment of insulin resistance [HOMA-IR] was used to estimate insulin resistance
Results: HOMA-IR and BMI were not significantly different among groups [p>0.05]. A significant positive correlation was found between BMI and HOMA-IR in the high-normal TSH [p>0.059] and subclinical hypothyroidism [p>0.05] groups
Conclusions: HOMA-IR and BMI are important for the assessment of diabetes and cardiovascular diseases. We found no significant difference in HOMA-IR and BMI values among the three TSH reference range groups
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Index:
IMEMR
Main subject:
Tertiary Healthcare
/
Insulin Resistance
/
Body Mass Index
/
Obesity
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Pak. J. Med. Sci.
Year:
2015