Antioxidant enzyme activity and malondialdehydeconcentration in patients with urticaria induced by nonsteroidal anti-inflammatory drugs

Objective: The Urticaria caused by NSAIDs wasstudied for their antioxidant enzyme activity andmalondialdehyde [MDA] concentration

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Methodology: Patients were divided into twogroups; group one act as a control and the remaininggroup was urticaria patients. The levels of theThiobarbituric acid reactive substances [TBARS, asa marker of lipid peroxidation], superoxidedismutase [SOD], glutathione [GSH] and catalase[CAT] in the serum were estimated. The enzymaticactivity was estimated and compared with differentcategories of NSAIDs

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Results: In present studyCAT, SOD and lipid peroxidation product [MDA]were statistically different from that of healthycontrol and showed significant changes [p< 0.05]while GSH showed a non-significant [p>0.05]value

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Conclusion: It is concluded thatantioxidative system of the body is accelerated andshows variations in the patient of Urticaria.Moreover, present study shows the co-ordinatedenzymatic mechanism and the interrelationshipbetween enzymatic activities in allergy