Interferon production in patients with recurrent hereditary polyserositis
Medical Principles and Practice. 1990; 2 (3-4): 185-189
in English
| IMEMR
| ID: emr-17526
ABSTRACT
Peripheral blood cells, obtained from patients with recurrent hereditary polyserositis [RHP] during attack-free intervals, were found to produce less interferon-gamma than cells from healthy controls when stimulated with phytohaemagglutinin. A similar, although less pronounced hyporesponsiveness was observed for interferon-alpha, produced after stimulation with Sendai virus. Treatment of the patients with colchicine appeared to restore, or partly restore, the interferon-alpha and interferon-gamma responsiveness, although neither interferon could be demonstrated in sera from the patients. However, the RHP patients displayed significantly raised serum levels of beta 2-microglobulin, a substance whose synthesis is stimulated by interferon. The interferon abnormality in RHP may be a secondary phenomenon, but it cannot be excluded that it has a pathogenetic role in the development of the disease
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Serositis
/
Colchicine
Language:
English
Journal:
Med. Princ. Pract.
Year:
1990
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