Substrate-dependent activity of ERK and MEK proteins in breast cancer [MCF7], and kidney embryonic [Hek-293] cell lines, cultured on different substrates

ABSTRACT

Background: Breast cancer has been one of the most common types of cancer, as the leading cause of women death in world. Breast cancer has known as a heterogenic disease that the clinical path in different patients would be very different. Since the current classification has not covered the diverse clinical course of breast cancer, lots of efforts has done to find new biological markers. Integrins are hetero dimmer proteins of alpha and beta subunits on cell membrane. After binding to extra cellular matrix [ECM], integrins activate MAPK pathway that regulated different activities like survival, differentiation, migration, immunologic response. The interaction of integrins and ECM have a key role in cancer cell activities like survival and metastasis