[Functional assessment of mitochondrial DNA 4977 bp deletion in peptic ulcer disease]

ABSTRACT

Background and Aim: A peptic ulcer is a breach in the gastric or duodenal mucosa down to the submucosa. There is evidence concerning the role of Reactive Oxygen Species [ROS] in the genesis of such ulcers production of intracellular ROS along mitochondria oxidative phosphorylation [OXPHOS] predisposes the deletion of 4977 bp mtDNA. The aim of the present study was to evaluate the association of 4977 bp mtDNA deletion with peptic ulcer disease