Preclinical studies of [68]Ga-DOTATOC: biodistribution assessment in Syrian rats and evaluation of absorbed dose in human organs
Asia Oceania Journal of Nuclear Medicine and Biology. 2016; 4 (1): 19-29
in English
| IMEMR
| ID: emr-176188
ABSTRACT
Objective[s] Gallium-68 DOTA-DPhe[1]-Tyr[3]-Octreotide [[68]Ga-DOTATOC] has been applied by several European centers for the treatment of a variety of human malignancies. Nevertheless, definitive dosimetric data are yet unavailable. According to the Society of Nuclear Medicine and Molecular Imaging, researchers are investigating the safety and efficacy of this radiotracer to meet Food and Drug Administration requirements. The aim of this study was to introduce the optimized procedure for [68]Ga-DOTATOC preparation, using a novel germanium-68 [[68]Ge]/[68]Ga generator in Iran and evaluate the absorbed doses in numerous organs with high accuracy
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Organometallic Compounds
/
Rats
/
Octreotide
/
Receptors, Somatostatin
Limits:
Animals
Language:
English
Journal:
Asia Oceania J. Nucl. Med. Biol.
Year:
2016
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